A Multi-Purpose Logistics Module (MPLM) is a large pressurized container that was used on Space Shuttle missions to transfer cargo to and from the International Space Station (ISS). Two MPLMs made a dozen trips in the Shuttle cargo bay and initially berthed to the Unity module and later the Harmony module on the ISS. From there, supplies were offloaded, and finished experiments and waste were reloaded. The MPLM was then reberthed in the Shuttle for return to Earth. Three modules were built by the Italian Space Agency (ASI): Leonardo, Raffaello, and Donatello.[1]
The Leonardo module was modified in 2010 to turn it into the Permanent Multipurpose Module (PMM) and was permanently attached to the ISS during the STS-133 mission in March 2011. In July 2011, the Raffaello module was the primary payload on the final Space Shuttle mission. It returned with the Shuttle and was stored at the Kennedy Space Center. The Donatello module never launched.
MPLMs were flown on 12 of the 37 Space Shuttle missions to the ISS.